Author: William J. LaRochelle
Publisher: Springer Science & Business Media
ISBN: 1592598935
Size: 25.17 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 750
View: 4958

Get Book

The Oncogenomics Handbook

by William J. LaRochelle, release date 2007-11-09, The Oncogenomics Handbook Books available in PDF, EPUB, Mobi Format. Download The Oncogenomics Handbook books, An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Author: Wafik S. El-Deiry
Publisher: Springer Science & Business Media
ISBN: 159259851X
Size: 49.78 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 374
View: 5122

Get Book

Death Receptors In Cancer Therapy

by Wafik S. El-Deiry, release date 2007-11-15, Death Receptors In Cancer Therapy Books available in PDF, EPUB, Mobi Format. Download Death Receptors In Cancer Therapy books, An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
ISBN: 1588297144
Size: 63.60 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 735
View: 2354

Get Book

Transforming Growth Factor Beta In Cancer Therapy Volume I

by Sonia B. Jakowlew, release date 2008-02-28, Transforming Growth Factor Beta In Cancer Therapy Volume I Books available in PDF, EPUB, Mobi Format. Download Transforming Growth Factor Beta In Cancer Therapy Volume I books, Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Author:
Publisher:
ISBN:
Size: 42.38 MB
Format: PDF, Kindle
Category : Books
Languages : en
Pages :
View: 5690

Get Book

Book Review Index

by , release date 2006, Book Review Index Books available in PDF, EPUB, Mobi Format. Download Book Review Index books, Every 3rd issue is a quarterly cumulation.

Author: Marten H. Hofker
Publisher: Springer Science & Business Media
ISBN: 1592593402
Size: 45.78 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 374
View: 7331

Get Book

Transgenic Mouse

by Marten H. Hofker, release date 2003, Transgenic Mouse Books available in PDF, EPUB, Mobi Format. Download Transgenic Mouse books, A collection of readily reproducible methods for working with mice, and particularly for generating mouse models that will enable you to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented. Use effective methods for conditional and inducible gene expression Review mouse models for a wide range of genetic aberrations associated with human disease.

Author: Lieping Chen
Publisher: Springer Science & Business Media
ISBN: 9780306478420
Size: 31.40 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 141
View: 3988

Get Book

The B7 Cd28 Family Molecules

by Lieping Chen, release date 2003-10-31, The B7 Cd28 Family Molecules Books available in PDF, EPUB, Mobi Format. Download The B7 Cd28 Family Molecules books, The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This is evident from the explosive accumulation of literature, particularly in the last ten years. Recent years have witnessed rapid discoveries and characterization of new receptors and ligands in the family. These new pathways, although still in their infancy, have already brought much excitement to the field. However, until now, there has been no single volume to cover this entire area. This book was created to bring together state-of-the-art information and critical thinking from the leading investigators. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases. This is an excellent handbook and reference for immunologists, health professionals as well as medical students and graduate students in life science field.

Author: Ralph A. Bradshaw
Publisher:
ISBN: 9780121245474
Size: 60.89 MB
Format: PDF, ePub, Mobi
Category : Cell interaction
Languages : en
Pages : 709
View: 6041

Get Book

Handbook Of Cell Signaling

by Ralph A. Bradshaw, release date 2004, Handbook Of Cell Signaling Books available in PDF, EPUB, Mobi Format. Download Handbook Of Cell Signaling books, The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field): * Initiation: Extracellular and Membrane Events * Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation * Events in Intracellular Compartments * Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field! * Contains approximately 470 articles * Provides well-organized sections on each essential area in signaling * Includes discussion on everything from ligand/receptor interactions to organ/organism responses * Extremely user-friendly.

Author:
Publisher:
ISBN: 9780835246491
Size: 69.14 MB
Format: PDF, ePub, Mobi
Category : Literature
Languages : en
Pages :
View: 2251

Get Book

Books In Print 2004 2005

by , release date 2004, Books In Print 2004 2005 Books available in PDF, EPUB, Mobi Format. Download Books In Print 2004 2005 books,

Author:
Publisher:
ISBN:
Size: 53.68 MB
Format: PDF, ePub
Category :
Languages : en
Pages :
View: 6722

Get Book

Anticancer Research

by , release date 2009, Anticancer Research Books available in PDF, EPUB, Mobi Format. Download Anticancer Research books,

Author: Arseniy Yuzhalin
Publisher: Academic Press
ISBN: 0128013338
Size: 65.38 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 356
View: 4414

Get Book

Interleukins In Cancer Biology

by Arseniy Yuzhalin, release date 2014-06-27, Interleukins In Cancer Biology Books available in PDF, EPUB, Mobi Format. Download Interleukins In Cancer Biology books, Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. . Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer Categorizes and clarifies all interleukins based on their role in cancer Contains comprehensive and exhaustive information on each molecule